Understanding the Impact of Stress on Fertility: FSMG Launches New Research Study

Understanding the Impact of Stress on Fertility: New Research Study

At Fertility Specialists Medical Group (FSMG), we are committed not only to providing exceptional care, but also to advancing the science that supports reproductive health. We’re proud to share that our laboratory team has launched a new IRB-approved research study focused on better understanding the effects of stress on egg quality and whether protective measures can help mitigate potential damage.

What We’re Studying

For years, studies in animal models have shown that elevated stress levels and the accompanying rise in cortisol can increase the likelihood of chromosomal abnormalities (aneuploidy) in oocytes (eggs). These abnormalities are often linked to disruptions in spindle function, which plays a critical role in properly dividing chromosomes during egg development.

However, human reproduction is far more complex. Despite the clear patterns in animal research, science has yet to confirm whether cortisol has the same impact on human eggs. That’s where our study comes in.

Our Goal

This research aims to examine whether there is a measurable relationship between:

• • Serum cortisol levels (a key stress hormone)
  • Stress markers in oocytes
  • The functional health of spindles during egg development

We are also exploring the potential of melatonin, a powerful antioxidant, to reduce these stress-induced changes. Early studies suggest melatonin may protect spindle function and improve egg quality in vitro. We hope to build on this promising data to improve the culture systems used during IVF and, ultimately, patient outcomes.

How the Study Works

This study will use oocytes that are not suitable for fertilization and would normally be discarded after retrieval. Participants will include women in two age groups: under 35 and over 38. Oocytes from individuals aged 35 to 37 will also be used in proof-of-concept testing and are highly encouraged to enroll.

Participants will:

• • Complete two standard fasting blood draws during their IVF cycle. These will be used both for routine monitoring and for research cortisol testing. (Cortisol results are for research purposes only but can be shared upon request after retrieval.)
  • Fill out a short questionnaire on stress and lifestyle at the time of egg retrieval.
  • Agree not to begin or stop any lifestyle habits, supplements, or medications during participation.

To ensure data integrity, participants should not be currently taking oral melatonin or any other daily antioxidants for more than six months.

All participant information will be kept confidential. Participation in the study will not affect your clinical care.

Why This Matters

Infertility can be stressful, and understanding how stress affects reproductive biology may unlock new strategies to improve outcomes. With this study, we hope to take a step toward better supporting our patients not only physically, but emotionally and biologically as well.

Interested in Participating?

If you are currently undergoing treatment at FSMG and would like to participate in this important study, please fill out our interest form below:

You may also speak with your care team or contact our lab for more information. Your participation could help shape the future of fertility care.